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Age-related reduction in the maximal capacity for sleep--implications for insomnia

mTORC1 regulates glutathione levels through ATF4-mediated induction of Slc7a11 Cysteine, generally acquired through cystine uptake and reduction, is an essential component of the tripeptide glutathione (Figure 6A), the most abundant antioxidant in cells (Meister, 1983)

Despite the advances in therapeutic interventions, numerous inescapable detrimental repercussions, such as the emergence of multi-drug resistance, continue to impede the effectiveness of the treatment regimens (116, 117)

doi: 10.1152/physrev.00044.2005 5 Bernal-CondeL

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